Scientist Medicinal Chemistry (m/w/d)

Stellenbeschreibung

Indivumed Therapeutics is a global oncology company, with a focus on bioinformatics and multi-omics-based oncology R&D. We look back on over twenty years of innovation, driven by a vision that remains unchanged to this day: To enable precision medicine and truly individualized cancer therapies. Striving for this goal we have unlocked an understanding of the molecular reality of cancer at an unparalleled level that is now supporting biomarker and therapeutic target discovery and validation, drug development, and clinical validation.

Whether as a scientist or a physician, as a data analyst, or in a corporate function, there are many ways you can contribute to our purpose. As a visionary, international company, we provide ample opportunities for your professional advancement and career development along the way. Join us in shaping the path to individualized cancer therapy!

Your responsibilites

We are establishing a team of chemists and physicist and you will contribute to shaping and implementing the chemical
and bio-physical activities in the areas of hit identification, hit expansion/refinement as well as lead identification.
From the target characterisation department, you obtain validated cancer treatment protein targets for which
biochemical and biophysical screening assays have been established. Within the group you have the following tasks:

• Contribute to Medicinal Chemistry/overall project related strategies for innovative drug discovery projects from hit identification through to candidate nomination
• Structure-based compound identification:

-Prepare protein targets for virtual ligand screening
-Select libraries for virtual screening
-Prepare the ligands for virtual screening
-Perform the virtual docking search and create a docking-score ranked list of compounds

• Support the advancement of compounds through in vitro and in vivo studies to identify development candidates. Discuss the setup of validation experiments with the target characterisation group
• Analyse results from this group
• Design and perform hit refinement and lead identification, design experiments with target characterisation group and analyse their results
• Contribute to hit and lead patenting

Our Requirements

• PhD in chemistry, pharmaceutics or medicinal chemistry
• Solid experience in academic or corporate medicinal chemistry with a focus on the following methods: (i.) Hit identification: Target protein preparation for screening from X-ray structure, library selection or sampling, ligand preparation, docking algorithm result evaluation. (ii.) Hit expansion and lead generation from hits.
• Knowledge of computational chemistry, structure-based drug design, molecular and cellular biology and pharmacology
• Excellent skills in English, at least good oral and written skills in German
• Demonstrated capabilities in problem-solving and creative scientific approaches
• Ability to prepare written and oral reports including publications and project plans, provide technical input, and make presentations

Our benefits

• Demanding area of responsibility in a fast-growing company
• Grant for the HVV ProfiTicket/Deutschlandticket
• Subsidy for sports membership and events
• Company pension scheme
• Company doctor
• Fresh fruits and drinks
• Christmas and summer party
• Flexible working hours
• German and English courses
• 30 days holiday
• The 24th and 31st of December are holidays and won´t be deducted from your annual holidays.

Would You Like to Contribute to the Success of Our Company?

Please apply online and include your salary expectations and current notice period.

Kontakt

Indivumed GmbH